Phenylpropanoids and polyketides
Medchemexpress LLC Xanthohumol | 6754-58-1 | 99.9% | 354.40 | 5 MG
Xanthohumol is a principal flavonoid isolated from hops. It inhibits diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2, and demonstrates anti-cancer, anti-angiogenic, and antiviral activities against viruses like bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Derived from hops
- Inhibits diacylglycerol acetyltransferase (DGAT)
- Inhibits COX-1 and COX-2
- Exhibits anti-cancer activity
- Exhibits anti-angiogenic activity
- Possesses antiviral activity
- Classified as a flavonoid, chalcone, phenol, and polyphenol
Medchemexpress LLC 5Z-7-oxozeaenol | 253863-19-3 | MFCD12912700 | 99.6% | 362.37 g/mol | C19H22O7 | 5 MG
5Z-7-Oxozeaenol is a natural, fungal-derived small molecule that acts as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2. It is used in biochemical and cellular research to probe TAK1- and VEGFR2-mediated signaling; reported IC50 values are 8 nM for TAK1 and 52 nM for VEGF-R2. The compound is supplied as a solid with high purity suitable for research applications.
- Potent, irreversible inhibition of TAK1 (IC50 = 8 nM).
- Selective activity against VEGF-R2 (IC50 = 52 nM).
- High purity suitable for biochemical and cellular assays.
- Solid form convenient for handling and storage.
- Useful for studying MAPKKK-mediated signaling pathways.
Selleck Chemical LLC Puerarin 5mg 3681-99-0 Kakonein
Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Cinnamyl alcohol (standard) | 104-54-1 | MFCD00002921 | 99.4% | 134.18 g·mol⁻1 | C9H10O | 50mg
Cinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohole (HY-Y0078) This product is intended for research and analytical applications Cinnamyl Alcohol is an active component from chestnut flower inhibits increased PPAR expression exhibits anti-obesity antioxidant and anti-inflammatory activities[1]
Medchemexpress LLC Cinnamyl alcohol | 104-54-1 | MFCD00002921 | 134.18 | C9H10O | 5g
Cinnamyl Alcohol is an active component from chestnut flower inhibits increased PPAR expression exhibits anti-obesity antioxidant and anti-inflammatory activities[1]
Cayman Chemical ANTIBODY AMG 9810 25mg
A competitive antagonist of capsaicin activation of the TRPV1 (IC50s = 24.5 and 85.6 nM for human and rat, respectively); reverses thermal and mechanical hyperalgesia in a rat model of inflammatory pain
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 100mg, CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Sigma Aldrich Fine Chemicals Biosciences Epigallocatechin 3 galla50MG
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity water residual solvents inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH Co. KG
Medchemexpress LLC 5Z-7-Oxozeaenol | 253863-19-3 | 99.3% | 10 MG
5Z-7-Oxozeaenol is a natural anti-protozoan compound of fungal origin, serving as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2, with IC50 values of 8 nM and 52 nM, respectively.
- Potent, irreversible, and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC50: 8.1 nM).
- Less active on MEK1 (IC50: 411 nM).
- Prevents inflammation by inhibiting TAK1 MAPK kinase kinase catalytic activity.
- Inhibitor of VEGF-R2 (IC50: 52 nM).
- Also inhibits VEGF-R3 (IC50: 110 nM), FLT3 (IC50: 170 nM), PDGFR-β (IC50: 340 nM), B-RAF VE (IC50: 6300 nM), and SRC (IC50: 6600 nM).
- Inhibits JNK/p38 pathway (signal-specific, not a direct inhibitor).
- Suppresses PMA-induced AP-1 activity in KT cells; no effect on IL-1-induced NF-kB activity in KK cells.
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Sigma Aldrich Fine Chemicals Biosciences Rivaroxaban R enantiomer U20MG
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Medchemexpress LLC Apigenin-7-O-sulfate potassium | 120562-19-8 | 99.9% | 388.39 | C15H9KO8S | 1mg
Apigenin-7-O-sulfate is a major flavonoid which is found to be a distinctive feature of plants from the Bay of Cadiz and can be extracted from these plants[1]
Medchemexpress LLC 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | >=96.0% | 1 G
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It is a blue fluorescent dye used for labeling proteins and nucleic acids.
- Blue fluorescent dye
- Amine-reactive succinimidyl ester
- Used for labeling proteins and nucleic acids
Medchemexpress LLC Apigenin-7-O-sulfate potassium | 120562-19-8 | 99.9% | 388.39 g·mol⁻1 | C15H9KO8S | 5mg
Apigenin-7-O-sulfate is a major flavonoid which is found to be a distinctive feature of plants from the Bay of Cadiz and can be extracted from these plants[1]